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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2012 May 22;1824(8):974–982. doi: 10.1016/j.bbapap.2012.05.006

Fig. 4.

Fig. 4

Effects of CpG methylation on the structure and structural dynamics of the terminal regions of nucleosomal DNA.5S rDNA nucleosomes display two unevenly distributed FRET states, a 0.29 FRET state (A) and a 0.4 FRET state (B) [14]. Signal integration time is 15 ms. After incubation with CpG methyltransferase, the population of nucleosome showing excursions to a high 0.74 FRET state was increased from 0.4% to 16% [14]. Examples of smFRET time trajectories that displayed excursions to a high 0.74 FRET state from 0.29 and 0.4 FRET states are shown in (C) and (D), respectively.