Table 1.
Modification of translation initiation factors both prior to and during apoptosis and their involvement in inhibition of general cap-dependent translation (middle column) and selective translation dependent on cis-elements (right column).
| Translation initiation factor | Modifications of initiation factors involved in inhibition of cap-dependent translation | Involvement of modified initiation factors in selective translation dependent on cis-elements |
|---|---|---|
| eIF2 | .Phosphorylation of eIF2α [5,8–10] | .Relief of uORF-mediated translation initiation [44–47] |
| .Caspase cleavage of eIF2α [15,16] | ||
|
| ||
| eIF2B | .Phosphorylation of eIF2Bɛ [17–19] | |
|
| ||
| eIF3 | .Caspase cleavage of eIF3j [23] | |
| .Phosphorylation of eIF3f by CDK11 [24] | ||
| .Interaction of eIF3c or eIF3e with ISG56/IFIT1 [21] | ||
| .Sequestration by eIF4G caspase cleavage fragments [36] | ||
|
| ||
| 4E-BP1/2 | .Caspase cleavage of 4E-BP1 [30] | |
|
| ||
| eIF4F | ||
| eIF4E | .Sequestration by hypophosphorylated and cleaved 4E-BP1/2 [29,30] | |
| .Sequestration by eIF4GI/II-caspase-cleavage fragments [36] | ||
| eIF4AI/II | .Interaction with PDCD4 [33] | |
| .Sequestration by eIF4GI/II-caspase-cleavage fragments [36] | ||
| eIF4GI/II | .Phosphorylation of eIF4GI by PAK2 [35] | |
| .Caspase cleavage of eIF4GI and eIF4GII [36] | ||
|
| ||
| PABP | .Caspase cleavage [39] | |
| .Sequestration by eIF4GI/II-caspase-cleavage fragments [36] | ||
|
| ||
| P97/DAP5 | .Induction of IRES-mediated translation [53–55] | |