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. 2012 Dec 27;14(1):480–495. doi: 10.3390/ijms14010480

Figure 2.

Figure 2

Schematic representation of miRNA-mediated inhibition of translation. The RISC complex loaded with a miRNA interferes with the cap recognition by eIF4F and the recruitment of ribosomal subunits 60S and 40S, preventing the ribosome complex formation and leading to inhibition of translation initiation. (Adapted from [11]).