Table 2.
Chemical structures and in vitro antifungal activity of compounds 1–24 against A. fumigatus and A. flavus.
A. fumigatus | A. flavus | ||||||||
---|---|---|---|---|---|---|---|---|---|
|
|
||||||||
Compound | Chemical Structures | ATCC 16913 (log1/cMIC) | IPP 210 | ATCC 46913 | ATCC 40640 | LM 247 | ATCC 16013 | LM 210 | LM 26 |
1 |
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1024 (2.15) | 1024 | 1024 | 1024 | 1024 | 1024 | 1024 | 1024 |
2 |
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64 (3.40) | 64 | 64 | 64 | 128 | 128 | 128 | 128 |
3 |
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≥2048 (1.89) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
4 |
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≥2048 (1.89) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
5 |
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≥2048 (1.89) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
6 |
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≥2048 (1.93) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
7 |
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1024 (2.26) | 1024 | 1024 | 1024 | ≥2048 | 1024 | 1024 | 1024 |
8 |
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≥2048 (2.21) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
9 |
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≥2048 (1.97) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
10 |
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≥2048 (2.00) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
11 |
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64 (3.49) | 64 | 64 | 64 | 256 | 64 | 64 | 64 |
12 |
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64 (3.50) | 64 | 64 | 64 | 128 | 64 | 64 | 64 |
13 |
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≥2048 (2.16) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
14 |
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256 (2.89) | 256 | 256 | 256 | 256 | 256 | 256 | 256 |
15 |
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16 (4.10) | 16 | 16 | 16 | 16 | 16 | 16 | 16 |
16 |
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128 (3.25) | 128 | 128 | 128 | 1024 | 1024 | 1024 | 1024 |
17 |
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≥2048 (2.05) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
18 |
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≥2048 (2.16) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
19 |
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≥2048 (1.99) | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 | ≥2048 |
20 |
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32 (3.80) | 64 | 32 | 32 | 1024 | 32 | 32 | 64 |
21 |
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512 (2.68) | 512 | 512 | 512 | 512 | 512 | 512 | 512 |
22 |
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16 (4.11) | 16 | 16 | 16 | 16 | 16 | 16 | 16 |
23 |
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512 (2.69) | 512 | 512 | 512 | 512 | 512 | 512 | 512 |
24 |
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1024 (2.30) | 1024 | 1024 | 1024 | 1024 | 1024 | 1024 | 1024 |
AmpB* | 2 | 2 | 2 | 2 | 8 | 2 | 2 | 512 |
AmpB, Amphotericin B.