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. 2013 Jan 14;14(1):1566–1588. doi: 10.3390/ijms14011566

Figure 1.

Figure 1

(a) RUNX1 is a hub of miRNAs targeting RUNX1 and miRNAs targeted by RUNX1. A number of miRNAs (>60 predicted by Targetscan, of which shown are only the ones experimentally validated) can inhibit RUNX1 protein expression by targeting the 3′UTR of RUNX1 mRNA. RUNX1 is predicted to target more than 200 miRNAs (shown are only the ones experimentally validated) and either repress or activate their transcription. Some miRNAs, such as miR-17 and miR-27, in turn can target RUNX1 in a feedback loop (dotted arrow). (b) Examples of possible RUNX1-miRNA feedback loops involved in megakaryocytic, monocytic, and granulocytic differentiation. In the latter case, RUNX1 may control miR-27 transcription indirectly, via CCAAT/enhancer-binding protein alpha (CEBPA) (dotted arrow).