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TS-miRNAs and their target mRNAs encoding proteins that enable cancer traits. Boxes depict five major cancer traits: Growth and Proliferation (blue), Cell Survival (red), Angiogenesis (green), Suppression of Immune Recognition (brown) and Invasion and Metastasis (purple). For each cancer trait, TS-miRNAs are indicated in white, the pro-oncogenic proteins encoded by mRNAs that are targets of TS-miRNAs are indicated in yellow and the cancer traits in orange.
