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. 2013 Jan 22;14(1):2085–2103. doi: 10.3390/ijms14012085

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© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Synergy analysis of the MMP9/MMP2i with cisplatin and combination in the A2780cis cell line. The median-effect function of Chou and Talalay, assuming mutual exclusivity, using the CombiTool (version 2.001; IMB Jena Biocomputing Group: Jena, Germany) was applied to analyze the Bliss independence reference model. Plots show the different combination indices at various effect levels (fraction affected) for an experimental design in which the doses of cisplatin varied in the presence of a fixed dose of MMP-9/MMP2i. Values are means for 3 experiments (n = 4 for the 3 h experiment). The coefficient of variation for each set of experiments was <10%. An additive effect has been observed.