TABLE 1.
Microarray Analysis of Cortex
| Top Canonical Pathways | p-valuea | Ratiob |
|---|---|---|
| Glutamate Receptor Signaling | 0.00038 | 11/69 |
| Axonal Guidance Signaling | 0.00095 | 39/430 |
| TOP MOLECULES | |
|---|---|
| Up-Regulated | Fold-Changec |
| KDM5B – lysine (K)-specific demethylase 5B | 8.26 |
| PRPF4B – alcohol group acceptor phosphotransferase, snRNP | 7.93 |
| BECN1 – beclin 1, autophagy related | 7.91 |
| STK4 – serine/threonine kinase 4 | 7.84 |
| BAZ1A – bromodomain adjacent to zinc finger domain, 1A | 7.63 |
| ROBO3 – roundabout, axon guidance receptor, homolog 3 | 7.18 |
| CYP – cytochrome P450, family 7, subfamily B, polypeptide 1 | 6.99 |
| PISD - phosphatidylserine decarboxylase | 6.90 |
| IKBKB - inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase β | 6.60 |
| MESDC2 – mesoderm development candidate 2 | 6.30 |
| Down-Regulated | Fold-Change |
|
| |
| FAM40B – family with sequence similarity 40, member B | 9.15 |
| MBP – myelin basic protein | 7.75 |
| PDE10A – 3′,5′-cyclic-nucleotide phosphodiesterase, Pde | 7.08 |
| ARPC3 – actin related protein 2/3 complex, subunit 3, 21kDa | 7.05 |
| LMO4 – LIM domain only 4 | 6.80 |
| SLC35D3 – solute carrier family 35, member D3 | 6.75 |
| SEMA7a – semaphoring 7A, GPI membrane anchor | 6.58 |
| CAMK2A – calcium/calmodulin-dependent protein kinase II alpha | 6.48 |
| MID1 – midline 1 | 6.07 |
| GNG7 – G protein beta gamma | 5.69 |
a
Canonical pathways were determined by Ingenuity using Benjamini-Hochberg multiple testing correction to determine p value.
b
The ratio represents the number of focused molecules as a function of the total number of molecules in that process.
c
Fold change relative to vehicle control.