Table 1.

Growth Factors and cellular Effects.

Growth Factor	Cellular Factor
PDGF Platelet Derived Growth Factor	Macrophage activation and angiogenesis Fibroblast chemotaxis and proliferative activity Enhances collagen synthesis Enhances the proliferation of bone cells
IGF-1 Insulin-like Growth Factor-I	Chemotactic for myoblast and fibroblasts and stimulates protein synthesis Mediator in growth ad repair of skeletal muscle Enhances bone formation by proliferation and differentiation of osteoblasts
TGF-p Transforming Growth Factor-β	Enhances the proliferative activity of fibroblasts Stimulates biosynthesis of type I collagen and fibronectin Induces deposition of bone matrix Inhibits osteoclast formation and bone resorption Regulation in balance between fibrosis and myocyte regeneration.
PDEGF Platelet Derived Endothelial Growth Factor	Promotes wound healing by stimulating the proliferation of keratinocytes and dermal fibroblasts
PDAF Platelet Derived Angiogenic Factor	Induces vascularization by stimulating vascular endothelial cells
EGF Endothelial Growth Factor	Cellular proliferation Differentiation of epithelial cells
VEGF Vascular Endothelial Growth Factor	Angiogenesis Migration and mitosis of endothelial cells Creation of blood vessel lumen Creation of fenestrations Chemotactic for macrophages and granulocytes Vasodilation (indirectly by release of nitrous oxide)
HGF Hepatocyte Growth Factor	Stimulates of hepatocyte proliferation and liver tissue regeneration Angiogenesis Mitogen for endothelial cells Antifibrotic