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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Pain Med. 2012 Apr;13(Suppl 2):S27–S36. doi: 10.1111/j.1526-4637.2011.01311.x

Figure 1.

Figure 1

Age-related responses of animals to different temperatures. Animals ranging in age from 8–32 months were evaluated on the thermal escape task for responses to 15°C (A), 10°C (B), 42°C (C) and 44.5°C (D). Accumulated escape durations in seconds are represented on the y-axis, and response numbers in a given session are represented on the x-axis. To control for possible effects of age on activity levels, differences between the cumulative escape durations for nociceptive stimulation and the cumulative escape durations for 36°C stimulation are plotted. For each temperature the maximal response durations (i.e. greatest sensitivity) was observed for animals 24–32 months of age, while the lowest response durations (i.e. least sensitivity) were for the youngest animals. (Published with permission from Oxford University Press).