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L-ASM activities of transiently expressed ASM variants in HeLa and MDCK cells
| HeLa cell lysates | MDCK cell lysates | |||
|---|---|---|---|---|
| Construct | ASM activity (pmol/mg/h) |
% Wild-type activity |
ASM activity (pmol/mg/h) |
% Wild-type activity |
| Wild-type ASM | 24,579 | 100 | 35,679 | 100 |
| p.A487V | 26,014 | 106 | 34,229 | 95 |
| p.P325A | 915 | 1 | 5,778 | 1 |
| Mock control | 1,230 | 5,536 | ||
