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. 2012 Jul 29;8:109–119. doi: 10.1007/8904_2012_168

Table 1.

Domains used to assess strength of evidence

 Risk of bias: Reflects issues in study design and conduct that could result in biased estimates of effect
 Consistency: Reflects similarity of effect sizes seen across studies. Consistency cannot be assessed when only one study is available
 Directness: Reflects the relationship between the intervention and the ultimate health outcome of interest
 Precision: Reflects the level of certainty around the effect observed