variables |
X |
expression of pro-endocrine transcription factor Ngn3
|
0 (initial) |
|
Y |
expression of transcription factor Ptf1a
|
0 (initial) |
|
|
average Ngn3 expression in neighbouring cells |
0 (initial) |
|
|
average Ptf1a expression in neighbouring cells |
0 (initial) |
parameters |
a |
strength of lateral inhibition |
1 |
|
b |
strength of lateral stabilization |
20 |
|
c |
strength of intracellular inhibition |
1 |
|
θ |
external activation |
0.1 |
|
n |
Hill coefficient |
4 |
|
ηx
|
amplitude of Gaussian white noise on X
|
10−4
|
|
ηy
|
amplitude of Gaussian white noise on Y
|
0 |
observables |
τx
|
time until symmetry break in X
|
|
|
τy
|
time until super-induction of Y
|
|
|
ε |
ratio of endocrine cells |
|