Table 1.

Conus purpurascens conopeptides: Potency, pharmacological targeting and source location

	Conopeptide	Sequence	IC50	Target	Source	Ref.
Neuromuscular	αA-PIVA	GCCGSYONAACHOCSCKDROSYCGQ*	2.3 nM	adult mouse muscle nAChR	MV	Hopkins et al. 1995
	α-PIA	RDPCCSNPVCTVHNPQIC*	0.95 nM	rat nAChR subtype rα6/α3β2β3	cDNA1	Dowell et al. 2003
	α-PIB	ZSOGCCWNPACVKNRC*	36 nM	adult mouse muscle nAChR	MV	Lopez-Vera et al. 2007
	μ-PIIIA	ZRLCCGFOKSCRSRQCKOHRCC*	44 nM	mammalian Nav	cDNA1	Shon et al. 1998a
	κ-PVIIA	CRIONQKCFQHLDDCCSRKCNRFNKCV	57 ± 4 nM	K+ shaker channel	MV	Shon et al. 1998
	ψ-PIIIE	HOOCCLYGKCRRYOGCSSASCCQR	127 nM 14 μM	torpedo nAChR adult mouse muscle nAChR	MV	Shon et al. 1997
	ψ-PIIIF	GOOCCLYGSCROFOGCYNALCCRK*	19 μM ~ 1 mM	torpedo nAChR adult mouse muscle nAChR	MV	Wagoner et al. 2003
Excitotoxic	δ-PVIA	EACYAOGTFCGIKOGLCCSEFCLPGVCFG*	Excitatory activity2	voltage-sensitive Nav	MV	Shon et al. 1995
	κA-PIVE	DCCGVKLEMCHPCLCDNSCKNYGK*	Excitatory activity2	-	MV	Teichert et al. 2007
	κA-PIVF	DCCGVKLEMCHPCLCDNSCKKSGK*	Excitatory activity2	-	MV	Teichert et al. 2007
Unclassified	d-Trp Contryphan-P	GCOWDPWC*	-	-	DV	Jacobsen et al. 1998
	d-Leu Contryphan-P	GCVLLPWC	-	-	MV	Jacobsen et al. 1998
	PVA	GCCPKQMRCCTL	-	-	MV	Jacobsen et al. 1998
	P1.9	CRWLQHSCLQ	-	-	cDNA1	-
	Conantokin-P	GEγγHSKYQγCLRγlRVNKVQQγC	0.3-2.3nM	NMDA Receptor NR2A/NR2B	cDNA1	Gowd et al., 2008

*, C-terminal amidated; W, d-Tryptophan; L, d-Leucine; Z, pyroglutamic acid; O, 4-trans-Hydroxyproline; γ, γ-carboxylglutamic acid; MV, Milked Venom; DV, Duct Venom;

¹cDNA was prepared by reverse transcription of RNA isolated from the C. purpurascens venom duct

²IC₅₀ on target channel is unknown.