Table 3. Symptom remission by antidepressant and ABCB1 genotype.
| dbSNP ID | N | Symptom remission (HDRS≤7) according to genotype | ORa | 95% CI | P-value | ||
|---|---|---|---|---|---|---|---|
| Escitalopram | |||||||
| rs1045642 (C3435T) | 57 | CC: 8/13 (61.5%) | CT: 16/29 (55.2%) | TT: 11/15 (73.3%) | 1.25 | 0.52–3.02 | 0.614 |
| rs2032582 (G2677T/A) | 57 | CC: 6/12 (50.0%) | CT: 22/35 (61.0%) | TT: 8/10 (80.0%) | 1.84 | 0.44–4.63 | 0.192 |
| rs1128503 (C1236T) | 57 | CC: 8/14 (57.1%) | CT: 18/30 (60.0%) | TT: 9/13 (69.2%) | 1.16 | 0.46–2.92 | 0.748 |
| Venlafaxine | |||||||
| rs1045642 (C3435T) | 41 | CC: 1/8 (12.5%) | CT: 11/18 (61.1%) | TT: 11/15 (73.3%) | 6.69 | 1.72–25.9 | 0.006b |
| rs2032582 (G2677T/A) | 41 | CC: 4/9 (44.4%) | CT: 8/20 (40.0%) | TT: 10/12 (83.3%) | 4.04 | 1.27–12.8 | 0.018 |
| rs1128503 (C1236T) | 41 | CC: 4/9 (44.4%) | CT: 6/14 (42.9%) | TT: 12/18 (66.6%) | 1.92 | 0.77–4.80 | 0.165 |
Abbreviations: ABCB1, ATP-binding cassette family of transporter proteins, subfamily B (MDR/TAP), member 1; CI, confidence interval; HDRS, 17-item Hamilton Depression Rating Scale; OR, odds ratio; SNP, single-nucleotide polymorphism.
a
Adjusted for ethnicity and education.
b
Significant after Bonferroni correction (P<0.017 needed).