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. 2012 Nov 13;2(11):e185. doi: 10.1038/tp.2012.112

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Copyright © 2012 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Genes correlating to clinical evolution and predictive of outcome. (a) Spearman's correlation between HDRS score evolution and mRNA expression level for PPT1 (Spearman's correlation factor=0.67, P=0.009). Each circle indicates, for a specified MDE patient (the label attached to the circle refers to the case number in Table 1), the difference of HDRS scores at inclusion and 8 weeks after inclusion as a function of the PPT1 FC for MDE_0w sample, calculated with the 2^−ΔΔCt method. The calibrator was a mathematical pool of control sample Ct. Normalization was performed using GAPDH and PAFAH1B1. (b) ROC curve for the combined expression of four transcripts (that is, HIST1H1E, IL1B, PPT1 and TNF) to predict treatment response after 8 weeks. With the highest Youden index, the combination score has a sensitivity value of 100% (54.1–100), specificity value of 77.78% (40–97.2), a positive predictive value of 75% and a negative predictive value of 100%.