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. 2013 Jan 6;10(78):20120617. doi: 10.1098/rsif.2012.0617

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© 2012 The Author(s) Published by the Royal Society. All rights reserved.

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Figure 5. — The effect of the detection limit on the estimate of the average turnover rate, , when fitting the BrdU labelling data of memory T cells in uninfected and SIV-infected rhesus macaques [13]. We consider three threshold levels, , 0.125 or 0.25, corresponding to the 4, 3 or 2 divisions, respectively, that a BrdU⁺ cell must undergo to result in BrdU⁻ progeny. Diamonds denote uninfected monkeys, squares denote SIV-infected monkeys with a low viral load, and circles denote monkeys with a high viral load in the study of Mohri et al. [13]. This analysis illustrates that the estimate of the average turnover rate depends on but not strongly.

Inline graphic — The effect of the detection limit on the estimate of the average turnover rate, , when fitting the BrdU labelling data of memory T cells in uninfected and SIV-infected rhesus macaques [13]. We consider three threshold levels, , 0.125 or 0.25, corresponding to the 4, 3 or 2 divisions, respectively, that a BrdU⁺ cell must undergo to result in BrdU⁻ progeny. Diamonds denote uninfected monkeys, squares denote SIV-infected monkeys with a low viral load, and circles denote monkeys with a high viral load in the study of Mohri et al. [13]. This analysis illustrates that the estimate of the average turnover rate depends on but not strongly.