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Spontaneous locomotor activity. On WD1 (a and c) and on WD14 (b and d), locomotor activity was measured during 24 h according to the protocol paradigm. The arrows indicate the usual hours of injection during the intermittent or binge treatment. Results were expressed in counts per hour (mean±s.e.m.). *P<0.05, Bonferroni test (n=9–14). B, binge; BC, binge cocaine; BS, binge saline; I, intermittent; IC, intermittent cocaine; IS, intermittent saline.
