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. 2012 Oct 23;2(10):e175. doi: 10.1038/tp.2012.103

Figure 5.

Figure 5

Extracellular dopamine (DA) in the nucleus accumbens core (Nacc) following an acute cocaine challenge. The dialysis samples were collected every 30 min out of the injection hour. The basal concentrations of DA in the Nac core, measured before the challenge injection, were (ng ml−1) for WD1, IS: 1.135±0.144, n=9; IC: 0.979±0.060 n=14; BS: 1.129±0.138, n=11; BC: 0.987±0.069, n=11 and for WD14, IS: 1.259±0.217, n=10; IC: 1.001±0.041, n=10; BS: 1.032±0.076, n=12; BC: 1.005±0.098, n=12. Results were expressed as percent (mean±s.e.m.) of baseline value obtained before a challenge administration of cocaine or saline (black arrow) out of the usual hours of injection treatment. **P<0.01 IS saline challenge vs IS cocaine challenge. ^^P<0.01, ^^^P<0.001 IC saline challenge vs IC cocaine challenge. +P<0.05, ++P<0.01 BS saline challenge vs BS cocaine challenge. $$P<0.01, $$$P<0.001 BC saline challenge vs BC cocaine challenge. #P<0.05 BS cocaine challenge vs BC cocaine challenge; two-way ANOVA (n=4–7). BC, binge cocaine; BS, binge saline; c, cocaine challenge; IC, intermittent cocaine; IS, intermittent saline; s, saline challenge.