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. 2012 Oct 9;2(10):e167. doi: 10.1038/tp.2012.82

Figure 1.

Figure 1

The association of white matter (WM) volume in psychotic disorders with genotypic variation in neuregulin 1 (NRG1) and myelin oligodendrocytes glycoprotein (MOG). (a) C-allele carrier genotype of the NRG1 single-nucleotide polymorphism (SNP), SNP8NRG221533 is associated with lower white matter volume in the region of the uncinate fasciculus (UF) in patients with schizophrenia (SZ). Scatter plot of mean (±s.e.m.) white matter volume across the TT versus C-carriers genotype groups in all five diagnostic categories in a sphere of 2 mm radius centered on the cluster peak (12 14 −16) implicating the UF in SZ. Beneath is the cluster T-map overlaid on sections of the MNI152 T1 template. (b). The risk genotype (TT) of the NRG1 SNP8NRG221533 and bipolar I disorder (BD) is associated with reduced white matter volume in the posterior inferior portion of the cingulum, parahippocampal gyrus and in the callosal body. Scatter plot of mean (±s.e.m.) white matter volume in a sphere of 2 mm radius centered on the posterior cingulum/parahippocampal gyrus cluster peak (−16 −12 −28). Top right illustrates the cluster extent and magnitude on a T-map, bottom right, the callosal body cluster effect for the finding in the same group and direction. (c). BD and having the HAPICE haplotype is associated with greater white matter volume in the posterior portion of the cingulum bundle. Scatter plot of mean (±s.e.m.) white matter volume in a sphere of 2 mm radius centered on the cluster peak (28 −40 −10) and adjacent, the cluster T-map overlaid on slices (Z −10 to −6 mm) of the functional MRI (fMRI)B58 FA map. (d). Psychiatrically healthy controls who are G-homozygotes of the MOG SNP rs2857766 have greater corticospinal tract white matter volume at the level of the medulla relative to C-carriers. Scatter plot of mean (±s.e.m.) white matter volume in a sphere of 2 mm radius centered on the cluster peak (6 −28 −40), middle panel illustrated the cluster on a statistical T-map. The cluster peak is at the level of the medulla in the right corticopontine/corticospinal tract and this is indicated by the crosshairs on sagittal and axial views of the fMRIBs mean FA map (FMRIB58_FA). L, left; R, right.