Table 2. Odds ratio of being classified as AD or MCI compared with a healthy control classification.
| Modela | Number of subjects included in model | Classification | OR | 95% CI | P-value |
|---|---|---|---|---|---|
| Model 1 | 970 | HC | 1.00 (reference) | ||
| MCI | 0.809 | 0.71–0.92 | ** | ||
| AD | 0.740 | 0.66–0.83 | *** | ||
| Model 2 | 970 | HC | 1.00 (reference) | ||
| MCI | 0.863 | 0.75–1.00 | * | ||
| AD | 0.813 | 0.71–0.93 | ** | ||
| Model 3 | 970 | HC | 1.00 (reference) | ||
| MCI | 0.866 | 0.75–1.00 | * | ||
| AD | 0.806 | 0.71–0.92 | ** |
Abbreviations: AD, Alzheimer's disease; APOE, apolipoprotein E; CI, confidence interval; HC, healthy control; MCI, mild cognitive impairment; OR, odds ratio. Multinomial logistic regression analysis; *P<0.05, **P<0.01 and ***P<0.001.
a
Model 1: unadjusted. Model 2: adjusted for age at assessment, sex, country of birth, education, APOE E4 allele status, current smoking status, caloric intake and BMI. Model 3: adjusted for covariates in model 2 and history of stroke, diabetes, hypertension, angina and heart attack.