FIG 3 .

OG-L002 potently inhibits HSV-1 IE gene expression and viral yield in both HeLa and HFF cells. HeLa (A to C) or HFF (D to G) cells were treated with the indicated concentrations (millimolar or  micromolar) of TCP, OG-L002, clorgyline, or DMSO control for 4 h, followed by infection with HSV-1 (0.1 PFU/cell) (A and B and D to F). mRNA levels of viral and cellular genes were measured by qRT-PCR at 2 h postinfection and expressed as ratios to the levels of the DMSO control (C and G). Viral yields were determined at 24 h postinfection. In panel C, 1 mM TCP and 50 µM OG-L002 were used.