FIG 5 .
Treatment of mice with OG-L002 reduces HSV primary infection in vivo. (A and B) BALB/c mice were treated with vehicle, acyclovir (ACV) (100 mg/kg/day), or OG-L002 (indicated amounts) and infected with HSV-2 intranasally. At the indicated days postinfection, viral loads in the trigeminal ganglia were determined by qPCR. (A) Viral loads in trigeminal ganglia at days 3 and 5 postinfection at an LD90 (1.1 × 105 PFU/mouse) (n =3). (B) Viral loads in trigeminal ganglia at days 3, 5, and 10 postinfection at an LD50 (1.1 × 104 PFU/mouse). Mice (n = 5) were treated with OG-L002 at 20 mg/kg/day.