FIG 6 .

OG-L002 blocks HSV-1 reactivation from latency. (A and B) Halves of bisected trigeminal ganglia from HSV-1 latently infected mice were explanted in the presence of control DMSO or TCP (2 mM) (A) and DMSO or OG-L002 (10 µM or 50 µM) (B) for 48 h. Viral yields were determined by titration on Vero cells. Statistical analyses were done using Wilcoxon matched-pair signed-rank test (DMSO versus TCP, P = 0.0005, n = 12; DMSO versus OG-L002 [10 µM]), P = 0.0021, n = 33; DMSO versus OG-L002 [50 µM], P < 0.0001, n = 27).