Table 3.
Frequencies of concomitant diseases in CF patients with different TNF-α and LT-α gene polymorphisms
| Genotype | Asthma | Tuberculosis | Virus hepatitis |
|---|---|---|---|
|
TNF-α–308 GG |
5.8% |
5.0% |
6.3% |
| (n = 145) |
(8/145) |
(7/140) |
(8/143) |
|
TNF-α–308GA |
14.0% |
2.9% |
3.8% |
| (n = 53) |
(7/53) |
(2/51) |
(2/53) |
|
P-value |
0.068 |
0.94 |
0.9 |
|
LT-α + 252AA |
6.5% |
8.3% |
6.4% |
| (n = 110) |
(7/110) |
(9/108) |
(7/109) |
|
LT-α + 252GA |
7.8% |
0% |
0% |
| (n = 67) |
(5/67) |
(0/65) |
(0/65) |
|
LT-α + 252GG |
10.0% |
0% |
16.7% |
| (n = 12) |
(1/12) |
(0/11) |
(1/12) |
|
P value |
|
PA/A,G/A = 0.013 |
PA/A,G/A = 0.035 |
| PA/A,G/G+G/A = 0.007 | PA/A,G/G+G/A = 0.088 |