Table 1.
Antimicrobial susceptibility of 65 Neisseria gonorrhoeae isolates from India (n=40), Pakistan (n=18), and Bhutan (n=7) in 2007–2011
| Antimicrobial | Breakpoints (susceptible/resistant, mg/L) | MIC range (mg/L) | Resistant, number (%) | Intermediate susceptible, number (%) | Susceptible, number (%) |
|---|---|---|---|---|---|
| Ciprofloxacin |
S≤0.03/R>0.06a |
0.064->32 |
61 (93.8) |
4 (6.2) |
0 (0) |
| Penicillin Gb |
S≤0.06/R>1a |
0.016->32 |
44 (67.7) |
20 (30.8) |
1 (1.5) |
| Erythromycinc |
S≤0.25/R>0.5c |
0.032-128 |
40 (61.5) |
8 (12.3) |
17 (26.2) |
| Tetracycline |
S≤0.5/R>1a |
0.125-64 |
36 (55.4) |
22 (33.8) |
7 (10.8) |
| Azithromycin |
S≤0.25/R>0.5a |
0.016-4 |
5 (7.7) |
10 (15.4) |
50 (76.9) |
| Spectinomycin |
S≤64/R>64a |
4-16 |
0 (0) |
0 (0) |
65 (100) |
| Ceftriaxone |
S≤0.12/R>0.12a |
<0.002-0.064 |
0 (0) |
0 (0) |
65 (100) |
| Cefixime | S≤0.12/R>0.12a | <0.016-0.064 | 0 (0) | 0 (0) | 65 (100) |
aBreakpoints according to The European Committee on Antimicrobial Susceptibility Testing. (EUCAST (http://www.eucast.org; Clinical breakpoints v2.0)).
bβ-lactamase was produced by 34 (52%) of the examined isolates, and all these isolates were considered as resistant to penicillin G independent on their MIC values.
cBecause of the lack of EUCAST breakpoints, the EUCAST breakpoints for azithromycin were used also for erythromycin.
MIC, minimum inhibitory concentration.