Fig. 3.

Ligand bias at MOR. The intrinsic efficacies (operational model) of a range of structurally dissimilar MOR agonists to activate [³⁵S]GTPγS binding and arrestin recruitment was determined and the bias factor (β) calculated according to the method of Rajagopal et al. (2011). Reproduced from Rivero et al. (2012).