Fig. 3.

Evidence for blood-to-brain drug transport mediated by Oatp1a4 at the BBB. Previous in vivo studies have shown that CNS uptake of drugs such as opioid peptide analgesics (e.g., DPDPE) and HMG-CoA reductase inhibitors (e.g., pitavastatin, rosuvastatin) is determined by functional expression of Oatp1a4 at the luminal and abluminal plasma membrane of the brain microvascular endothelium. AP, apical; BL, basolateral.