Figure 2. The photon flux maximum and timing are dependent on the route of substrate administration.

a, b) The PE_max and AUC increase corresponding to the physiologically expected biodistribution for sc, ip and iv substrate administration, reflected by the characteristic time activity curves. c) Maximal photon flux is reached at minimal time for iv injections followed by ip and sc (* statistically significant difference with p≤0.05 to standard protocol 150 mg/kg post-Iso in post hoc comparison with Sidak correction).