Table 1. Subset of phosphoproteins analyzed in Younossi et al. ⁸ appearing in the five most enriched pathways.

Phosphoprotein	Function	Pathway(s)
IRS-1	docking protein	regulation of lipid metabolism by insulin
		signal transduction by AKT
		signal transduction by PIP3
		IGF-1 receptor signaling
		regulation of translation by insulin
SHC	protein domain	regulation of lipid metabolism by insulin
		signal transduction by PIP3
		IGF-1 receptor signaling
		regulation of translation by insulin
AKT	kinase	regulation of lipid metabolism by insulin
		signal transduction by AKT
		signal transduction by PIP3
		IGF-1 receptor signaling
		regulation of translation by insulin
P70-S6	kinase	regulation of lipid metabolism by insulin
		signal transduction by AKT
		signal transduction by PIP3
		IGF-1 receptor signaling
		regulation of translation by insulin
PKA-c	kinase	regulation of lipid metabolism by insulin
mTOR	kinase	regulation of lipid metabolism by insulin
		signal transduction by PIP3
		IGF-1 receptor signaling
		regulation of translation by insulin
4E-BP1	translation	regulation of lipid metabolism by insulin
		signal transduction by AKT
		signal transduction by PIP3
		IGF-1 receptor signaling
		regulation of translation by insulin
p90 RSK1	kinase	regulation of lipid metabolism by insulin
		signal transduction by PIP3
		IGF-1 receptor signaling
		regulation of translation by insulin
GSK-3	kinase	signal transduction by AKT
		signal transduction by PIP3
		IGF-1 receptor signaling
FOXO3A	transcription factor	signal transduction by AKT
		signal transduction by PIP3
		IGF-1 receptor signaling
BAD	apoptosis	signal transduction by AKT
		signal transduction by PIP3
		IGF-1 receptor signaling
CREB1	transcription factor	signal transduction by PIP3
		IGF-1 receptor signaling
eIF4G	translation	regulation of translation by insulin