Figure 3. Combination therapy with anti-CD20 and proinsulin plasmid does not offer protection after T1D onset.

NOD mice with hyperglycemia (2 consecutive readings of BGV>180 mg/dl), were treated with either (A) weekly administration of 50 µg proinsulin plasmid or (B) 100 (upper panel) or 250 µg of anti-CD20 alone or (C) 50 (upper panel) or 250 µg of anti-CD20 antibody in combination with weekly administration 50 µg of proinsulin plasmid. Each line represents one individual mouse.