Figure 4. Combination therapy with anti-CD20 and proinsulin plasmid prevents T1D more efficiently.

Eight to ten week old prediabetic NOD mice were treated with (A) weekly administration of 50 µg proinsulin plasmid only or, (B) one-time administration of anti-CD20 alone or, (C) anti-CD20 administered in combination with four weekly administrations of proinsulin plasmid. Statistical tests were performed by Kaplan-Meier analysis using Graphpad Prism software.