Table 5. GO Results for genes with microsatellites that overlap with G4 elements.

Ontology	Category	Hyper FDR Q value	Hyper fold enrichment	Number of genes found
GO Biological Process	Signal release	3.39684e−7	2.1533	52
	Cartilage development	2.28192e−6	2.0690	41
	Negative regulation of B cell activation	5.84903e−5	4.4914	11
	Multicellular organismal homeostasis	1.20456e−4	2.1504	27
	Regulation of ion transmembrane transporter activity	1.87001e−4	2.1324	32
	Camera-type eye morphogenesis	5.21582e−4	2.0009	30
	Neurotransmitter secretion	5.19828e−4	2.1208	29
	Spinal cord anterior/posterior patterning	5.76268e−4	10.1377	1
	Tissue homeostasis	1.08506e−3	2.1131	21
	Regulation of long-term	1.25384e−3	3.0197	13
	neuronal synaptic plasticity
	Hormone secretion	1.42278e−3	2.2221	22
	Hormone transport	1.76257e−3	2.1627	23
	Negative regulation of synaptic transmission, glutamatergic	3.77337e−3	6.1327	3
	Elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger	3.92996e−3	5.2566	5
	Peptide hormone secretion	4.22613e−3	2.2528	18
PANTHER Pathway	TGF-beta signaling pathway	4.57321e−4	2.0458	32
	General transcription regulation	6.12838e−3	3.1400	35
	Ras Pathway	6.46098e−3	2.0119	22
	Beta2 adrenergic receptor signaling pathway	2.56959e−2	2.0132	15
	Gamma-aminobutyric acid synthesis	2.90416e−2	4.7309	3
	Transcription regulation by bZIP transcription factor	3.47807e−2	2.0310	14

Gene ontology (GO) results for genes that contain microsatellites that overlap with G4 elements in their promoter. Hyper FDR Q-value is the false discovery rate q-value, Hyper fold enrichment is the enrichment of the test set on the overall (control) set for each category. 2,666 genes contain a G4 that overlaps with a microsatellite. For a control set we used genes that contain G4 elements in their promoters, for a total of 14,977 genes. The promoter region here was again 5 kb upstream and down of the TSS.