Table 5. The ten-fold cross-validation performance of metal binding sites on Cross-Validation dataset.

ETMB-RBF with different features	True Positive	False Positive	True Negative	False Negative	Sensitivity	Precision	Specificity	Accuracy	MCC
Metal binding cysteine
AA	60	22	90	19	75.9%	73.2%	80.4%	78.5%	0.56
BLOSUM62	65	12	100	14	82.3%	84.4%	89.3%	86.4%	0.72
PAM250	58	9	103	21	73.4%	86.8%	92.0%	84.3%	0.67
PSSM	76	16	96	3	96.2%	82.6%	85.7%	90.1%	0.81
PSSM+SAAPs	78	12	100	1	98.7%	86.7%	89.3%	93.2%	0.87
Metal binding histidine
AA	37	30	226	40	48.1%	55.2%	88.3%	79.0%	0.38
BLOSUM62	43	21	235	34	55.8%	67.2%	91.8%	83.5%	0.51
PAM250	39	37	219	38	50.6%	51.3%	85.5%	77.5%	0.36
PSSM	60	13	243	17	77.9%	82.2%	94.9%	91.0%	0.74
PSSM+SAAPs	62	8	248	15	80.5%	88.6%	96.9%	93.1%	0.80