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. 2013 Feb 6;8(2):e55264. doi: 10.1371/journal.pone.0055264

Figure 4. The effect of KLK, ODN1a and IC31® on the expression of IRF family transcription factors and type I IFNs.

Figure 4

Human moDCs were differentiated for 5 days in the absence (control) or presence of KLK, ODN1a or IC31® added on day 0, 2 and 5 (Protocol B, Figure S2) to the cultures or on day 5 only (Protocol C). Relative expression of IRF1, IRF3 and IRF7 as well as IFNA1, IFNA2, IFNB1 genes was measured in resting (empty bars) and 100 ng/ml LPS +10 ng/ml IFNγ-activated (black bars) DCs by QPCR. Mean±SEM values of triplicate measurements were calculated from data of 3 independent donors.