Table 1.
Gain-of-Function Cho Organ Phenotypes
| Driver | Gene/Construct | % Partial/Complete Transformationa |
% Total Defectsb |
Number/Type of Hemisegmentsc |
|---|---|---|---|---|
| Elav | EP-robo2 | 44 | 58.4 | 457 abd |
| Atonal | EP-robo2 | 30.5 | 40 | 151 abd |
| Elav | UAS-robo2d | 21 | 41 | 56 abd |
| Elav | UAS-roboY→F | 6.1 | 8.7 | 196 abd |
| Elav | UAS-roboicc2cc3 | 0 | 0 | 119 abd |
| Elav | UAS-robo3d | 0 | 0 | 364 abd |
| Elav | EP-robo2 (25°C) | 32 | 58 | 262 abd |
| Elav | EP-robo2; +/slit−(25°C) | 17.2 | 32.6 | 319 abd |
| Elav | EP-robo2, roboZ2130 | 36.4 | 49.4 | 324 abd |
| VM | EP-robo2 | 17 | 41 | 247 abd |
| 0 | 1.5 | 68 tho | ||
| VM | UAS-robo3d | 0 | 0 | 70 abd |
| VM | UAS-robo2-Δcytod | 5.4 | 14.2 | 742 abd |
| 9 | 10.8 | 212 tho | ||
| VM | UAS-roboY→F | 0.2 | 0.7 | 406 abd |
| 0 | 0.9 | 114 tho |
All experiments were performed at 29°C unless specified otherwise.
Abbreviations: abd, abdominal segments; tho, thoracic segments.
a
Similar to triple or double asterisked examples shown in Figure 2J.
b
Similar to any of the defects shown in Figure 2J.
c
Thoracic segments were unaffected unless specified otherwise.
d
robo2 and robo3 transgenes are myc-tagged.