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. Author manuscript; available in PMC: 2013 Nov 30.
Published in final edited form as: Oncogene. 2012 Jul 16;32(22):2756–2766. doi: 10.1038/onc.2012.294

Figure 5.

Figure 5

Knockdown of Jab1 impairs DNA repair and decreases expression of the DNA repair gene Rad51. (a) (Left) RPPA analysis of cisplatin (CP)- and UV- treated NPC cells. Cell lysates were harvested after treatment with 5 μM CP or 40 J/m2 UV for 48 h. Samples were organized by treatment, which is indicated on the right side of the heat-map. (Middle and Right) The response of the cells to CP or UV was normalized against the response of untreated cells. (c, d) HONE1 cells were transfected with Jab1 or control siRNA 48 h before CP, UV or IR exposure. Cell lysates were prepared 48 h after CP, UV or IR exposure and western blotting was performed with the indicated antibodies related to DNA damage and repair proteins.