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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Hepatology. 2013 Feb;57(2):577–589. doi: 10.1002/hep.26081

Figure 2. TLR2−/− mice develop less liver fibrosis.

Figure 2

WT and TLR2−/− mice were fed CSAA diet (CS) or CDAA diet (CD) for 22 weeks. Closed bars represent WT mice and open bars indicate TLR2−/− mice. (A) Sirius red staining. Original magnification,×400. Bar 100 µm. (B) Sirius red positive area. Liver fibrosis was attenuated in TLR2−/− mice. (C) Immunohistochemical staining for αSMA. Original magnification,×400. Bar 100 µm. (D) Western blotting for αSMA. (E) mRNA expression of fibrogenic genes. Genes were normalized to 18S RNA as an internal control. Data represent mean ±SD, *p<0.05. n.s.; not significant.