Table 1.
Standard chow | CSAA | CDAA | ||||
---|---|---|---|---|---|---|
WT mice (n = 7) |
TLR2−/− mice (n = 7) |
WT mice (n = 10) |
TLR2−/− mice (n = 7) |
WT mice (n = 10) |
TLR2−/− mice (n = 9) |
|
Body weight (g, start, wk=0) | 22.5 ± 0.95 | 21.4 ± 0.65 | 21.5 ± 1.13 | 22.9 ± 0.93 | 23.0 ± 1.74 | 21.0 ± 0.82 |
Body weight (g, end, wk=22) | 30.9 ± 1.22 | 29.5 ± 0.73 | 42.0 ± 2.52a | 33.8 ± 1.75 | 42.8 ± 2.02a | 33.5 ± 1.94c |
Liver weight (g) | 1.22 ± 0.14 | 1.15 ± 0.22 | 1.88 ± 0.21a | 1.37 ± 0.53 | 2.54 ± 0.38a,b | 1.54 ± 0.28c |
Liver weight (%) | 3.71 ± 0.75 | 3.80 ± 0.66 | 4.44 ± 0.73a | 4.05 ± 0.68 | 5.50 ± 0.64a,b | 5.11 ± 0.58c |
Epididymal fat (g) | 0.96 ± 0.22 | 0.87 ± 0.36 | 2.24 ± 0.76a | 1.25 ± 0.51 | 2.39 ± 0.52a | 1.01 ± 0.34c |
Epididymal fat (%) | 2.85 ± 0.34 | 2.95 ± 0.54 | 4.82 ± 0.91a | 4.00 ± 0.77 | 4.70 ± 0.75a | 3.53 ± 0.67c |
Plasma | ||||||
Triglyceride (mg/dl) | 36.5 ± 6.25 | 33.8 ± 4.82 | 55.3 ± 7.55 | 48.8 ± 6.12 | 70.5 ± 10.6a | 51.1 ± 8.76 |
Total cholesterol (mg/dl) | 70.3 ± 6.32 | 66.9 ± 7.12 | 143 ± 12.8a | 99.1 ± 15.8 | 99.6 ± 8.69 | 82.8 ± 7.93 |
Free fatty acid (mEq/L) | 0.40 ± 0.11 | 0.35 ± 0.08 | 0.47 ± 0.19 | 0.41 ± 0.13 | 0.50 ± 0.21 | 0.36 ± 0.12 |
Liver | ||||||
Triglyceride (mg/g liver) | 33.5 ± 3.91 | 30.7 ± 3.67 | 80.4 ± 8.81a | 54.3 ± 6.92 | 155 ± 19.5a,b | 150 ± 20.6 |
Total cholesterol (mg/g liver) | 11.6 ± 2.56 | 10.6 ± 1.68 | 17.5 ± 2.56 | 12.6 ± 1.05 | 23.7 ± 3.09a | 15.1 ± 2.61 |
Free fatty acid (mEq/g liver) | 0.60 ± 0.16 | 0.57 ± 0.17 | 2.79 ± 0.85a | 2.55 ± 0.51 | 3.08 ± 0.88a | 2.48 ± 0.62 |
Note: Values are mean ± SD.
Significantly different from WT on Standard chow, p<0.05.
Significantly different from WT on CSAA diet, p<0.05.
Significantly different from WT on CDAA, p<0.05.