Table 1.
Cardiovascular, cerebrovascular and thermoregulatory responses to hot flashes, categorized as Responders (n=16) and Non-responders (n= 9).
| Responders | Non-responders | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Baseline | Peak MAP decrease | Recovery | Baseline | Peak MAP decrease | Recovery | |
| MAP (mm Hg) | 90 ± 13 | 78 ± 12 *# | 85 ± 13 * | 91 ± 17 | 90 ± 19 | 92 ± 17 |
| SBP (mm Hg) | 120 ± 20 | 100 ± 19 *# | 115 ± 19* | 120 ± 27 | 118 ± 31 | 123 ± 27 |
| DBP (mm Hg) | 68 ± 9 | 57 ± 7 *# | 66 ± 10 | 68 ± 13 | 64 ± 7 * | 71 ± 12 |
| MCAv (cm.s−1) | 54 ± 20 | 47 ± 17 * | 51 ± 19 | 58 ± 17 | 54 ± 15 | 54 ± 14 |
| CBVC (cm.s−1.mm Hg−1) | 0.6 ± 0.2 | 0.6 ± 0.2 | 0.6 ± 0.3 | 0.7 ± 0.3 | 0.6 ± 0.2 | 0.6 ± 0.2 |
| HR (bpm) | 70 ± 7 | 74 ± 10 *# | 70 ± 6 | 75 ± 8 | 78 ± 11 # | 73 ± 6 |
| Δ Skin blood flow (AU) | 0 ± 0 | 41 ± 65*# | −8 ± 43 | 0 ± 0 | 47 ± 62*# | 0 ± 13 |
| Δ Sweat rate (mg/cm2.min−1) | 0 ± 0 | 0.22 ± 0.24*# | 0.00 ± 0.01 | 0 ± 0 | 0.18 ± 0.20*# | 0.00 ± 0.01 |
| Tcore (° C) | 37.2 ± 0.3 | 37.3 ± 0.3 | 37.2 ± 0.3 | 37.3 ± 0.1 | 37.4 ± 0.1 | 37.4 ± 0.2 |
| Tsk (° C) | 35.3 ± 0.9 | 35.4 ± 0.8 | 35.3 ± 0.7 | 36.0 ± 0.4 | 36.7 ± 1.8‡ | 36.7 ± 2.2‡ |
A Responder was identified upon a reduction in mean arterial pressure (MAP) of ≥5 mm Hg in any segment of the hot flash. SBP, systolic blood pressure; DPB, diastolic blood pressure, MCAv, middle cerebral artery blood velocity; CBVC, cerebrovascular conductance; HR, heart rate; Δ, delta change; Tcore; core body temperature; Tsk, mean skin temperature.
*
P <0.05, versus pre hot flash baseline;
#
P <0.05, versus post hot flash recovery;
‡
P <0.05, Non-responders different from Responders.