Table 1.
Biodistribution of the nanobeacon versus free Coumarin 6 dye two hours post treatment in an orthotopic mouse model.
| Nanobeacona | Coumarin 6b | |||
|---|---|---|---|---|
| Tissue weight (g) | Recovery (% of dose) | Tissue weight (g) | Recovery (% of dose) | |
| Intra-jenunal | ||||
| Jejunum | 0.342 ± 0.03 | 97.4 ± 8.5 | 0.26 ± 0.04 | 44.2 ± 8.4 |
| Liver | 0.838 ± 0.05 | 0.42 ± 0.3 | 1.04 ± 0.06 | 3.2 ± 0.8 |
| Kidney | 0.251 ± 0.03 | 0.063 ± 0.01 | 0.36 ± 0.05 | 0.96 ± 0.1 |
| Blood | -c | 0.11 ± 0.09 | -c | 2.03 ± 1.0 |
| Intra-colorectal | ||||
| Large Intestine | 0.241 ± 0.06 | 104 ± 4.3 | 0.2 ± 0.04 | 53.3 ± 7.5 |
| Liver | 0.846 ± 0.19 | n.d.d | 1.07 ± 0.12 | 2.86 ± 1.5 |
| Kidney | 0.308 ± 0.04 | n.d.d | 0.35 ± 0.02 | 0.63 ± 0.2 |
| Blood | -c | nd.d | -c | 2.12 ± 1.2 |
a
Injection dose 2mg/mouse
b
Injection dose 1.0 μg/mouse
c
Approximately 0.2mL of blood collected from the abdominal artery
d
Not detected