Fig. 3.

Link between structure and function: quantitative motor deficits are correlated to changes in FA. a Significant correlations between white matter FA reduction and GFV were found in areas associated with the primary somatosensory cortex and in the vicinity of the visual cortex (p < 0.0001, corrected for multiple comparisons, minimal cluster size 1,000 voxel, orange rendered regions represent t values between 1.72 and 6.11); b glass brain showing the areas of correlation; c regression analysis in ROI (post hoc) depicting high correlation between FA and GFV in the left hemisphere—see green area on right inlay—respective regions on both inlay images are marked by red circles; d–f regression analyses in the same ROI for AD, RD and MD are not significant (p > 0.05), but exhibit weak trends for all measures as may be appreciated in the plots. The biological meaning of these observations needs to be re-addressed in larger studies (AD axial diffusivity, a.u. arbitrary units, FA fractional anisotropy, GFV grip force variability, MD mean diffusivity, RD radial diffusivity)