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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Hepatology. 2013 Feb 7;57(3):1130–1141. doi: 10.1002/hep.26105

Figure 6.

Figure 6

Working model of changes induced by local modulation of AANAT in large biliary proliferation. Top: Exogenous melatonin, by interaction with type 1 (MT1) receptor, inhibits large cholangiocyte proliferation (hypoplasia), by increasing biliary AANAT expression and then melatonin secretion. Bottom: Downregulation of biliary AANAT levels by Vivo-Morpholino stimulates the proliferation of large cholangiocytes via the reduction of biliary AANAT expression and melatonin secretion that induces subsequent activation of biliary proliferation (hyperplasia).