Figure 3.

Inhibition of AsPC-1 tumor growth by CIK cells in nude mouse xenograft models. Nude mice (n=7) were implanted subcutaneously with nine million AsPC-1 cancer cells. CIK cells at doses of 1 (CIK 1), 3 (CIK 3), and 10 (CIK 10)×10⁶ cells/mouse were injected intravenously once a week. Adriamycin (ADR) was injected intravenously at 2 mg/kg. Tumor volumes were estimated by the formula: length (mm)×width (mm)×height (mm)/2 (A). On day 20, the mice were sacrificed and the tumor weights were measured (B). Representative photographs are shown (C). Statistical significance was determined using the ANOVA test versus PBS-treated control group (^*p<0.05, ^**p<0.01).