Inflammatory hyperalgesia induced by subcutaneous zymosan A injection into the plantar side of the left hindpaw. (A) mechanical PWTs (g, mean ± SEM) in response to stimulation with dynamic von Frey filaments were monitored before and 2 days after injection of zymosan A. On day 2, HZ166 (▼, ▽, 16 mg / kg body weight) or vehicle (●, ○) were injected i.p. and PWTs were monitored for 3 hours after HZ166 injection. n = 6 mice per group. (B) statistical analysis. AUC (g·h, mean ± SEM). **, P < 0.01 (unpaired t-test).