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. Author manuscript; available in PMC: 2013 Feb 7.
Published in final edited form as: Neuropharmacology. 2010 Dec 8;60(4):626–632. doi: 10.1016/j.neuropharm.2010.11.026

Fig. 4. Antihyperalgesic effects of HZ166 in the zymosan A model of inflammatory pain.

Fig. 4

Inflammatory hyperalgesia induced by subcutaneous zymosan A injection into the plantar side of the left hindpaw. (A) mechanical PWTs (g, mean ± SEM) in response to stimulation with dynamic von Frey filaments were monitored before and 2 days after injection of zymosan A. On day 2, HZ166 (▼, ▽, 16 mg / kg body weight) or vehicle (●, ○) were injected i.p. and PWTs were monitored for 3 hours after HZ166 injection. n = 6 mice per group. (B) statistical analysis. AUC (g·h, mean ± SEM). **, P < 0.01 (unpaired t-test).