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CHOP−/− mice develop more severe kidney injury than WT mice after LPS treatment. A: BUN levels were 1.6-fold higher in CHOP−/− mice compared with WT mice after LPS treatment (*P < 0.05). B: urine albumin excretion, expressed as albumin-to-creatinine ratio (ACR), increased significantly in both WT and CHOP −/− mice after LPS treatment. ACR in CHOP−/− mice was 7-fold higher than in WT mice (*P < 0.05).
