Fig. 4.

Glomerular cell number increases more in CHOP^−/− mice after LPS treatment. A: WT control mice. B: CHOP^−/− control mice. C: LPS-treated WT mice. D: LPS-treated CHOP^−/− mice. Representative periodic acid-Schiff-stained sections (×40). E: quantitation of glomerular cell number. LPS treatment caused a significant increase in glomerular cellularity in both WT and CHOP^−/− mice (*P < 0.05). Although CHOP^−/− animals had a lower number of glomerular cells at baseline, a 1.25-fold higher number of glomerular cells was present in CHOP^−/− compared with WT mice after LPS treatment (*P < 0.05). Data are expressed as means ± SD.