Fig. 6.

More apoptotic cell death in CHOP^−/− mice kidney after LPS treatment. The number of apoptotic cells was evaluated in kidneys of LPS-treated WT and CHOP^−/− mice with terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling staining. A: apoptotic nuclei (arrow) staining in kidneys of WT mice treated with LPS. B: apoptotic nuclei (arrows) staining in kidneys of LPS-treated CHOP^−/− animals. C: CHOP^−/− mice had 1.7-fold higher number of apoptotic nuclei compared with WT mice after LPS treatment (**P < 0.01). Data are expressed as means ± SD.