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Effects of urethane in a cumulative dosing manner (0.03–1.2 g/kg iv) on bladder and external urethral sphincter (EUS) electromyogram (EMG) activity during continuous-infusion CMGs (0.21 ml/min). Recordings were obtained 5–10 min after the administration of the drug indicated above each record. Note that bladder contraction pressure and concomitant EUS EMG activity are suppressed by increasing doses of urethane and are abolished by the 1.2 g/kg dose of urethane. pps, Pulses per second.
