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The ratio of plasma levels of single amino acids to plasma levels of the sum of all large neutral amino acids (∑LNAA). The increased valine/∑LNAA and leucine/isoleucine/∑LNAA ratios predict increased uptake through the blood-brain barrier (BBB). The decreased tyrosine/∑LNAA and tryptophan/∑LNAA ratios predict decreased uptake through the BBB (ANOVA: BCAA, P < 0.0001 for all 4 ratios). Data are presented as means ± SE (n = 5/group).
